By The International Agency for Research on Cancer
This eighty-ninth quantity of the IARC Monographs is the 3rd and final of a chain on tobacco-related brokers. quantity eighty three mentioned at the carcinogenicity of tobacco smoke and involuntary smoking (second-hand smoke or environmental tobacco smoke) (IARC, 2004a). quantity eighty five summarized the proof at the carcinogenic probability of chewing betel quid with and with no tobacco (IARC, 2004b). That quantity explored the diversity of goods chewed in South Asia and different components of the note that include areca nut together with different materials, frequently together with tobacco. during this eighty-ninth quantity, the carcinogenic dangers linked to using smokeless tobacco, together with chewing tobacco and snuff, are thought of in a primary monograph. the second one monograph stories a few tobacco-specific nitrosamines. those brokers have been evaluated previous in quantity 37 of the Monographs (IARC, 1985), and knowledge accrued when you consider that that point has been summarized and evaluated.
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3, The Design and Analysis of Long-term Animal Experiments (IARC Scientific Publications No. L. W. (1983) Implication of nonlinear kinetics on risk estimation in carcinogenesis. L. K. (1989) Occurrence and relevance of chemically induced benign neoplasms in long-term carcinogenicity studies. , 8, 1–21 IARC (1973–1996) Information Bulletin on the Survey of Chemicals Being Tested for Carcinogenicity/Directory of Agents Being Tested for Carcinogenicity, Numbers 1–17, Lyon, IARCPress IARC (1976–1996), Lyon, IARCPress Directory of On-going Research in Cancer Epidemiology 1976.
10. OTHER DATA RELEVANT TO AN EVALUATION OF CARCINOGENICITY AND ITS MECHANISMS In coming to an overall evaluation of carcinogenicity in humans (see pp. 25–27), the Working Group also considers related data. The nature of the information selected for the summary depends on the agent being considered. g. tobacco smoking), the other data considered to be relevant are divided into those on absorption, distribution, metabolism and excretion; toxic effects; reproductive and developmental effects; and genetic and related effects.
I) Carcinogenicity in humans The applicability of an evaluation of the carcinogenicity of a mixture, process, occupation or industry on the basis of evidence from epidemiological studies depends on the variability over time and place of the mixtures, processes, occupations and industries. The Working Group seeks to identify the specific exposure, process or activity which is considered most likely to be responsible for any excess risk. The evaluation is focused as narrowly as the available data on exposure and other aspects permit.
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