By H. J. Newbury
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Hence, background selection is considered efficient only if it permits a return to the recipient genome faster than the normal return rate when no selection on markers is applied; the efficiency of MAS should always be compared to this normal rate as a reference. We need first to recall what is the normal rate of return expected with no background selection. 1 Expected genome contents with no selection On non-carrier chromosomes (chromosomes not hosting the target), the probability that any locus remains heterozygous donor/recipient after n backcrosses is (½) n.
Et al. (1994) The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell, 78, 1073–1087. F. J. (1996) Towards developing inter-varietal substitution lines in Brassica napus using marker-assisted selection. Genome, 39, 348–358. J. W. (1995) QTL analysis: unreliability and bias in estimation procedures. Molecular Breeding, 1, 273–282. C. & Stam, P. (1994) High resolution of quantitative traits into multiple loci via interval mapping.