By Alireza Minagar MD FAAN
Multiple Sclerosis: A Mechanistic View offers a distinct view of the pathophysiology of a number of sclerosis (MS) and comparable issues. because the purely publication out there to target the mechanisms of MS instead of targeting the medical good points and remedy of the disorder, it describes the position of genetic and environmental elements within the pathogenesis of MS, the position of particular cells within the pathophysiology of the ailment, and the pathophysiology of inflammatory and neurodegenerative problems regarding MS.
The e-book offers dialogue of neurodegeneration and neuroregeneration, serious rising components of study, in addition to targeted dialogue of the mechanisms of motion of the authorized and investigational medications for remedy of MS and the rising function of magnetic resonance spectroscopy (MRI) in investigations into MS.
It is the single e-book out there to provide accomplished insurance of the identified mechanisms of MS and similar ailments, and includes contributions from physicians and researchers who're around the globe specialists within the box of analysis.
- Focuses at the pathophysiologic mechanisms of a number of sclerosis and the mechanisms of motion in brokers for the remedy of MS
- Discusses the jobs of neurodegeneration and neuroregeneration in MS and comparable diseases
- Authored and edited via overseas leaders within the box of MS research
Read Online or Download Multiple Sclerosis. A Mechanistic View PDF
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Extra resources for Multiple Sclerosis. A Mechanistic View
Example text
They also hinder the ability of DC in presenting antigens (Matsushita, Yanaba, Bouaziz, Fujimoto, & Tedder, 2008). , 2012). One important question is how can we activate Breg cells so they impose their immunomodulatory role? To date, it is not clear whether Breg cells preexist in the immune repertoire or are a by-product of immune response to specific stimuli. , 2008). To better understand the inhibitory mechanisms of Breg cells, IL-10 producing B cells were co-cultured with B cell activating factor.
This is true in the case of MS, which was thought to be a T cell disease until very recently. Studies have proven that, other than the old established role of producing antibodies, B cells have roles and responsibilities that potentially lead to autoimmune disease. These include presenting antigen to T cells, activating T cells, expression of costimulatory molecules, and production of cytokines. Identification of B lymphocyte subgroups, the potential of B cells for negative regulation of immune responses, and inflammation has been recognized and the idea of Bregs has surfaced.
00003-8 23 © 2016 Elsevier Inc. All rights reserved. 24 3. ROLE OF B CELLS IN THE PATHOGENESIS OF MS Like T cells, B cells play both positive and negative roles in the immune system. , 2008; LeBien & Tedder, 2008). • B cells are very potent APCs; during antigen presentation they induce abundant production of antigen-specific CD4+ T cells, memory cells, and cytokines (Crawford, Macleod, Schumacher, Corlett, & Gray, 2006; Linton, Harbertson, & Bradley, 2000). , 2007). , 2002). , 2001) • Peyer’s patch (Golovkina, Shlomchik, Hannum, & Chervonsky, 1999) • chemokines (Crowley, Reilly, & Lo, 1999).