By Curtis W. Slipman MD, Richard Derby MD, Frederick A. Simeone MD, Tom G. Mayer MD
As many as eighty% of sufferers will be afflicted by again ache sooner or later of their lifetime. it's the most typical kind of incapacity, and the second one biggest reason behind paintings absenteeism. An early, proactive administration strategy deals the easiest path to minimizing those stipulations. well known authority Curtis W. Slipman, MD and a workforce of multidisciplinary professionals current you with professional counsel on cutting-edge most sensible non-surgical administration equipment, equipping you with the information you want to supply your sufferers optimum discomfort relief.Refresh your wisdom of the elemental ideas that has to be understood earlier than sufferers with spinal ache could be competently treated.Know what to do while first-line exams and remedies fail, utilizing practice-proven diagnostic and healing algorithms.Offer your sufferers an entire variety of non-surgical healing procedures, together with pharmacology, actual treatment, injection concepts, ablative techniques, and percutaneous disc decompression.Make an educated surgical referral with information on symptoms, contraindications, tools, and postoperative rehabilitation.Better comprehend key recommendations and methods with visible suggestions from greater than 500 targeted illustrations.Download the entire book's illustrations from the accompanying CD-ROM to be used in digital displays.
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Extra info for Interventional Spine: An Algorithmic Approach
Sample text
Resident chondrocytes TNF-α Macrophage infiltration of disc tissue Neurovascularization Nerve conduction velocity reduction Factories for production of inflammatory mediators (TNF-α, IL-1, IL-6, NO) Nerve ingrowth Nerve sensitization DRG sensitization Back pain Radiculopathy Nitric oxide ↓ MCP-1 IL-8 MMP3/TIMP Matrix degradation response to abnormal loading Disc degeneration ↓ Upregulation MMP-7 TNF-α IL-1 (Many sources) MMP2/MMP3 Nitric oxide Matrix degradation Nerve effects Back pain IL-6/PGE2 Radiculopathy Fig.
Burke JG, Watson RWG, McCormack D, et al. Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg Br 2002; 84(2):196–201. Burke JG, Watson RWG, Conhyea D, et al. Human nucleus pulposus can respond to a pro-inflammatory stimulus. Spine 2003; 28(24):2685–2693. Caron JP, Fernandes JC, Martel-Pelletier J, et al. Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression.
Park JB, Kim KW, Han CW, et al. Expression of Fas receptor on disc cells in herniated lumbar disc tissue. Spine 2001; 26(2):142–146. Park JB, Chang H, Kim YS. The pattern of interleukin-12 and T-helper types 1 and 2 cytokine expression in herniated lumbar disc tissue. Spine 2002; 27(19):2125–2128. Pearce RH, Mathieson JM, Mort JS, et al. Effect of age on the abundance and fragmentation of link protein of the human intervertebral disc. J Orthop Res 1989; 7(6):861–867. Pendás AM, Knäuper V, Puente XS, et al.