By Richard A. Berger MD PhD, Arnold-Peter C. Weiss MD
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Example text
The latter represents a failure of the mechanical environment with a preserved biologic activity and usually responds to stabilization by internal fixation. In long-standing cases, uncontrolled movement between the fractured ends of bone results in eburnation and thickening of the fracture surfaces. The nonunion eventually gets enveloped in a fibrous scar, and the mobile, often painless, fracture begins to behave like a false joint or pseudarthrosis. The healing process is completely arrested, and a nonunion does not heal without surgical intervention to excise and freshen the fracture and to alter the local environment by increasing stability, improving vascularity, and grafting bone.
Purely osteoinductive, BMPs are used to augment autogenous or allogeneic cancellous graft (34). Ceramic-based bone substitutes have a consistent crystalline structure that is osteoconductive and has a predictable resorption rate. The addition of DBM can add osteoinductive properties to the material. Artificially prepared de novo or derived from coral, the handling properties of these substitutes can be modified by the addition of cement or plasticizing agents to create a variety of different physical forms, such as putty, pellets, or granules.
The superficial layers of cartilage are destabilized and begin to break down. Chondrocytes respond to alterations in the matrix by proliferation and increased synthetic activity to augment matrix production. The amplified activity can be sustained for many years and may restore the tissue to halt progression of the disease. Surgical intervention in early stages with procedures such as angular osteotomies can stimulate restoration of the cartilage surface by altering the adverse mechanical environment (108).
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