By Caroline Hollins-Martin, Olga Van Den Akker, Colin Martin, Victor R. Preedy
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Extra info for Handbook of Diet and Nutrition in the Menstrual Cycle, Periconception and Fertility
Sample text
2 Female reproductive physiology In humans, approximately 6-7 million of primordial follicles are present at 20 weeks of intrauterine life. The total number of primordial follicles drops to about 1-2 million at birth and 300,000 at puberty as a result of the ongoing follicular atresia. At puberty the hypothalamic-pituitaryovarian axis is activated, and the menstrual cycle starts. The process of folliculogenesis is a dynamic process, which is controlled by a complex network of endocrine and autocrine factors leading to the monthly development and release of a single oocyte (ovulation) in approximately two thirds of women.
G. 1. Hormone levels across the menstrual cycle. Fluctuations in levels of the gonadotrophic hormones lutenizing hormone (LH) and follicle stimulating hormone (FSH) and the ovarian steroid hormones estrogen and progesterone occur across the menstrual cycle. LH cues the release of estrogen and progesterone from the ovarian follicles and the corpus luteum. As shown here, in a 28-day menstrual cycle, the follicular phase begins on day 1 and concludes on day 14 with ovulation. The luteal phase follows which commences on day 15 and concludes on day 28.
The longer the time since the fatty acid changes were initiated (usually a function of aging), the greater will be the dysfunction of membranes and mitochondrial function. We might expect that mitochondrial enzymes might need to be administered – such as CoQ10 – and the results are likely to be better if this supplementation is administered in conjunction with fatty acids. As has already been demonstrated, supplementation with DHEA will reduce the risk of miscarriage in older women (aged 41 or older) who become pregnant.