By Laurence L. Brunton
A Doody's center identify crucial buy! five famous person DOODY'S evaluate! "The eleventh version of Goodman & Gilman remains to be the main complete and authoritative unmarried resource at the pharmacology of substances. the 1st version used to be released via Alfred Gilman and Louis Goodman in 1941. It quickly turned referred to as the bible of pharmacology and, although editorship and bankruptcy authorships have replaced consistently from variation to version, this continues to be the best of pharmacology textbooks....The print model will be at the reference shelf and the electronic model at the machine laptop of all working towards pharmacologists, pharmacists, and physicians."--Doody's evaluate provider (20060801)
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Additional resources for Goodman and Gilman's The Pharmacological Basis of Therapeutics, Eleventh Edition
Example text
Cancer, arthritis, myocardial infarction, and Crohn’s disease) lead to elevated levels of α1-acid glycoprotein and enhanced binding of basic drugs. Because binding of drugs to plasma proteins such as albumin is nonselective, and because the number of binding sites is relatively large (high capacity), many drugs with similar physicochemical characteristics can compete with each other and with endogenous substances for these binding sites, resulting in noticeable displacement of one drug by another.
These enzyme families, the major reactions they catalyze, and their role in drug metabolism and adverse drug responses are presented in detail in Chapter 3. , in blood or plasma). This relationship has been documented for many drugs and is of benefit in the therapeutic management of patients. For some drugs, no clear or simple relationship has been found between pharmacological effect and concentration in plasma, whereas for other drugs, routine measurement of drug concentration is impractical as part of therapeutic monitoring.
In addition, drug then passes through the liver, where metabolism and biliary excretion may occur before the drug enters the systemic circulation. Accordingly, a fraction of the administered and absorbed dose of drug will be inactivated or diverted before it can reach the general circulation and be distributed to its sites of action. If the metabolic or excretory capacity of the liver for the drug is large, bioavailability will be reduced substantially (the first-pass effect). This decrease in availability is a function of the anatomical site from which absorption takes place; other anatomical, physio- logical, and pathological factors can influence bioavailability (see below), and the choice of the route of drug administration must be based on an understanding of these conditions.