By Gardner, David K

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Human blastocysts grown in culture. Nature (London) 1971; 229: 132–3. 30. Edwards RG, Surani MAH. The primate blastocyst and its environment. Uppsala J Med Sci 1978; 22: 39–50. 31. Csapo AI, Pulkkinen MO, Kaihola HL. The relationship between the timing of luteectomy and the incidence of complete abortions. Am J Obstet Gycecol 1974; 118: 985–9. 32. Steptoe PC, Edwards RG. Reimplantation of a human embryo with subsequent tubal pregnancy. Lancet 1976; 1: 880–2. 33. Edwards RG, Steptoe PC, Purdy JM.

Artificial cycles were introduced in Australia and intracytoplasmic sperm injection (ICSI) in Belgium,38 and gonadotropin releasing hormone (GnRH) agonists were used to inhibit the LH surge. Ian Craft in London showed how postmenopausal women aged 52 or more could establish pregnancies using oocyte donation and endocrine support. Women over 60 years of age conceived and delivered children. This breakthrough was especially welcome to me, since older women surely have the right to have children at ages almost the same as those possible for men.

It was essential to conceive 100 or 1000 IVF babies to ensure that the method was safe and effective clinically. The immense delays in establishing Bourn Hall delayed our work by 2 years after Louise’s birth. Finally, on minimal finance, Bourn Hall opened in September 1980 on a shoestring, supported by our own cash and loans. The delay gave the rest of the world a chance to join in IVF. Alex Lopata delivered an IVF baby in Australia, and one or two others were born elsewhere. Natural-cycle IVF was chosen initially at Bourn Hall since it had proved successful in Oldham, and we became experts in it.

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Textbook of assisted reproductive techniques : laboratory by Gardner, David K
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