By Ramez N. Eskander, Robert E. Bristow
During this age of complicated know-how, there's a big volume of dynamic literature surrounding the analysis and therapy of gynecologic cancers. regardless of this knowledge surplus, condo officials and junior college learning gynecologic oncology point out a necessity for a competent, simply available, streamlined source for daily use. Gynecologic Oncology: A Pocketbook is a collaborative attempt that mixes the views of specialist school and fellows in education within the box of gynecologic oncology. not just is it really transportable, however the layout during which the data is gifted (bullet aspect, define, tables and diagrams) permits fast entry to worthy details and is exclusive among current texts. This certain pocketbook will give you the info had to deal with sufferers with gynecologic malignancies properly and may advertise severe pondering all through treatment.
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Extra info for Gynecologic Oncology: A Pocketbook
Cancer Res. 1984;44:4878s–83. 48. Ohno S, Siddik ZH, Kido Y, Zwelling LA, Bull JM. Thermal enhancement of drug uptake and DNA adducts as a possible mechanism for the effect of sequencing hyperthermia on cisplatin-induced cytotoxicity in L1210 cells. Cancer Chemother Pharmacol. 1994;34:302–6. 49. Nicoletto MO, Padrini R, Galeotti F, Ferrazzi E, Cartei G, Riddi F, Palumbo M, De Paoli M, Corsini A. Pharmacokinetics of intraperitoneal hyperthermic perfusion with mitoxantrone in ovarian cancer. Cancer Chemother Pharmacol.
1. 0 cm) the median survival was nearly 5 years in the carboplatin containing arm. • The combination of carboplatin and paclitaxel was then studied with gemcitabine, topotecan or liposomal doxorubicin in sequential doublets or triplets in GOG 182/ ICON5 . – This international trial recruited >4,000 women with advanced stage epithelial ovarian cancer. – There was no improvement in either PFS or OS associated with any experimental regimen. – Compared with standard paclitaxel and carboplatin, addition of a third cytotoxic agent provided no benefit in PFS or OS after optimal or suboptimal cytoreduction.
No difference in overall survival (only 1/3 of group optimally staged) No difference in HR for recurrence or death (29 % inadequately staged) No difference in recurrence or 5 year survival CT carboplatin/paclitaxel, T paclitaxel, GOG Gynecologic Oncology Group, ICON International Collaborative Ovarian Neoplasm, ACTION Adjuvant Chemotherapy Trial in Ovarian Neoplasia, HR hazard ratio Reprinted with permission from Cambridge University Press. Eskander RN, Di Saia PJ. Chemotherapy of ovarian cancer.
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