By T. J. Wolfensberger (auth.), Gabriel Coscas, Felice Cardillo Piccolino (eds.)
This quantity of Documenta Ophthalmologica complaints sequence collects the clinical papers provided on the 2d foreign Symposium on Retinal Pigment Epithelium and the 4th assembly of the ecu Macula team held in Genoa, may perhaps 29-June 1, 1996. The Symposium on Retinal Pigment Epithelium was once promoted through the college Eye health center of Genoa because the normal continuation of the 1st Symposium held with nice good fortune in Genoa in 1988. the former conferences of the eu Macula staff have been held in Coimbra (1988), Crete (1989) and Athens (1994). i used to be enormously happy and honoured to host the fourth congress of this distinct Society and i'm thankful to Gabriel Coscas, Jose Cunha-Vaz and George Theodossiadis, came upon ers of the Society, for choosing Genoa in this get together. the 2 conferences built-in good in an unicuum and taken jointly an outstanding variety of amazing retinal experts coming from worldwide. the entire facets of the present examine relating retinal pigment epithelial and macular ailments have been lined. numerous attention-grabbing shows seemed new options of retinal and choroidal imaging. an entire consultation used to be devoted to the most recent advances in tradition and transplantation of retinal pigment epithelial cells. Age-related macular degeneration used to be a huge topic for dialogue, together with new methods to therapy. This subject was once excessive lighted via a mini-symposium on drusen, together with a chain of magnificent lectures on class, clinicopathological reports, indocyanine eco-friendly imaging, and laser therapy for prevention of choroidal neovascularization.
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49 . e. above the RPE basement membrane) has also been observed 46 . 50-52. In association with these basement membrane changes, the basal border of the epithelial cells undergoes a reduction in the complexity of the basal invaginations suggesting a progressive decline of active transport with age. Over the age of 40 years, focal aggregations of sub-pigment epithelial debris are observed and these excrescences on Bruch's membrane are called drusen 3 . These deposits can be found both internal and external to the RPE basement membrane 46 .
3. , DeRobertis, E. Submicroscopic changes in visual cells of rabbit induced by iodoacetate. J Biophys Biochem Cyto!. 1959; 5: 245-261. 4. D. Differences in the retinotoxic action of chloroquine and phenothiazine derivatives. J Patho!. 1970; 102: 139-150. 5. , Henkind, P. Urethane-induced retinopathy in pigmented rats. Arch Ophthalmo!. 1973; 12: 65- 76. 6. l. Experimental model of gyrate atrophy in animals. Ophthalmology. 1981; 88: 331- 334. 7. l. Toxic effects of ornithine and its related compound on the retina.
1992; 110: 541- 546. 9. F. New hypothesis on the pathogenesis and treatment of serous retinal detachment. Graefe's Arch Clin Exp Ophthalmol. 1998; 226: 548- 552. 10. -Y. Conditions necessary for the formation of serous detachment: Experimental evidence from the cat. Arch Ophthalmol. 1994; 112: 830- 838. Department of Ophthalmology Stanford University Medical Center Stanford, CA 94305-5308 USA 4. Ageing of the human retinal pigment epithelium M. BOULTON and 1. WASSELL (Manchester. UK) Introduction The human retinal pigment epithelium (RPE) is a non-dividing system which throughout life undertakes a number offunctions essential for the maintenance of photoreceptor cells.