By Anatoliy Granov, Leonid Tiutin, Thomas Schwarz
This guide, written in a transparent and detailed kind, describes the rules of positron emission tomography (PET) and gives unique info on its software in medical perform. the 1st a part of the publication explains the actual and biochemical foundation for puppy and covers such subject matters as instrumentation, picture reconstruction, and the creation and diagnostic homes of radiopharmaceuticals. the point of interest then turns to using puppy in medical perform, together with its function in hybrid imaging (PET-CT). a variety of oncological purposes in numerous physique platforms and organs are mentioned, and makes use of of puppy in cardiology, neurology, and psychiatry also are addressed. attribute findings are defined and illustrated through quite a few photos, a lot of them in colour. This e-book might be of worth not just for nuclear drugs physicians and radiologists but additionally for oncologists, surgeons, cardiologists, neurologists, psychiatrists, and citizens with an curiosity in molecular imaging.
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Sample text
If the department has a mixed profile and cardiological examinations are expected, it is appropriate to include also a cardiologist in order to prepare patients and to do stress testing. 1 Characteristics of PET Examination Organization in Oncological Clinical Practice Organization of examinations in modern oncological practice has a number of distinctions. For preparation for a whole-body examination, the patient should stay at rest in the treatment room (lying on a couch) for no less than 30–40 min before and 38 2 Methodical Aspects of Using PET 15 min after the introduction of the RP.
A significant (more than 25%) decrease of SUV in the tumor focus as a result of treatment is estimated as a partial metabolic response. Absence of significant changes is regarded as process stabilization, and a significant increase in SUV (more than 25%) is considered as a sign of progression of the process. In order to obtain significant SUVs, as precise a reproduction as possible of the conditions of the previous examination of the patient is required. It should be noted that the interpretation of therapy results is possible without PET data obtained before the onset of treatment, but in this case it is not possible to differentiate a partial response or process stabilization without initial data.
Short half-lives of USLR require high level radioactivity to be supplied. This is why a radiochemical laboratory should be equipped in a sequence of special protective (“hot”) cells (Fig. 6a, b). As can be seen in the picture, boxes can have different types of construction and protection depending on the desired value of RP radioactivity. In the boxes automated modules are located which permit to synthesize RP as quickly as needed (Fig. 6c–e). In case of an unexpected situation caused by the breakdown of a module or by an error on the part of the personnel, one has to wait for radiation in the module to decrease to acceptable levels and to remove the malfunction.