By Paul Slack
This Very brief creation explores the historic influence of plague over the centuries, the ways that it's been interpreted, and the robust photos it has left at the back of in paintings and literature.
Paul Slack assesses its reasons, that have usually been disputed and at the moment are being illuminated by means of microbiologists and archaeologists, and he appears at attainable purposes for its periodic disappearance from entire continents. He exhibits what plague intended if you suffered from it, and the way governments started to struggle opposed to it and in doing so invented glossy notions of public wellbeing and fitness. His concentration in the course of the ebook is on how humans coped with demise and affliction in epidemic crises.
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Additional resources for Plague: A Very Short Introduction (Very Short Introductions)
Example text
Once the mechanism of a disease DIVERSE FUNDING MODELS 31 is understood, moreover, a proposed therapy must be testable. Cerezyme reverses the effect of Gaucher, but there are a number of diseases whose damage is not reversible, and the goal of a therapy is to slow the progression of the disease. Demonstrating decreased progression is very different statistically from showing reversal. Another challenge, alluded to earlier, is the practicality of running a clinical trial when the patient population is extremely small.
A therapy would have to be disease modifying and/or lifesaving. And it would have to be testable—a challenge given the small populations involved when one is dealing with rare diseases. Post-approval, Genzyme is committed to optimizing patient care, as opposed to simply convincing physicians that the treatment for their Gaucher patients is Ceredase. Thus the company seeks to facilitate an environment in which patients with Gaucher disease have a reasonable expectation of being seen and diagnosed by a disease expert so informed decisions can be made about therapy.
What are the truly neglected diseases? With 127 compounds in development, HIV/AIDS is not a neglected disease. For malaria there are only 30 drugs in development, many of which are in the early stages and have a high risk of failure. For tuberculosis (TB), and particularly drug-resistant TB, only 22 candidate drugs are in the pipeline. For truly neglected diseases, such as human African trypanosomiasis, Chagas disease, and dengue fever, the pipeline is very limited, including 5, 7, and 8 compounds, respectively.