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Itano, E. ; Xavier, E. C. ; Yamashita, C. ; Vieira, V. ; Menoli, A. ; Silva, S. ; Costa, F. ; Reiche, F. ; Silva, F. L. V. & Kaminami, M. S. (2002) Immune and hormonal activity in adults suffering from depression. 35, pp. 581-587, ISSN 1678-4510 Page, M. ; Detke, M. ; Kirby, A. D. L. G. & Lucki, I. (1999). Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test. 147, pp. 162–167, ISSN 1432-2072 Pellegrino, T. C. & Bayer, B. M. (2002). Role of Central 5-HT2 Receptors in FluoxetineInduced Decreases in T Lymphocyte Activity.
2011) Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. 6052, pp. ; Jaffuel, D. & Mathieu, M. (2007). Anti-inflammatory properties of desipramine and fluoxetine. 8, pp. ; Brennan, F. & Williams, R. (2010). Fluoxetine and Citalopram Exhibit Potent Antiinflammatory Activity in Human and Murine Models of Rheumatoid Arthritis and Inhibit Toll-like Receptors. 62, pp. 683–693, ISSN 1529-0131 Schleifer SJ, Keller SE, Meyerson AT, Raskin MJ, Davis KL, Stein M. (1984) Lymphocyte function in major depressive disorder.
Table 1. Effects of different doses of amitriptyline on IA learning, activity, anxiety and SDL in mice. Effects of Antidepressants on Inhibitory Avoidance in Mice: A Review 1. 2. 3. , 2002). 5, 15 and 30 mg/kg) were administered immediately after IA training. Subjects were tested for avoidance twenty four hours later. 5 and 30 mg/kg in CD1 females. The sex differences observed were limited to a slightly stronger effect of amitriptyline on IA in males than in females. These results indicate that acute amitriptyline administration produces retrograde amnesia in a IA task, which does not seem to be mediated by anxiolytic effects: when CD1 mice explored an elevated plus-maze during a five-minute period forty-five minutes after injection amitriptyline had no effect on anxiety (percentage of open arm entries) and induced a dose-dependent impairment of activity (number of closed arm entries), which did not affect IA, as the drug was administered after training (see conclusions regarding pharmacokinetic rationale).