By Jay R. Harris, Marc E. Lippman, C. Kent Osborne, Monica Morrow
Completely revised and up-to-date, and now in complete colour all through, the Fourth version of this definitive reference is a needs to for all clinicians who deal with breast ailments. prime specialists summarize the present wisdom of breast illnesses, together with their scientific gains, administration, underlying biologies, and epidemiologies. as well as whole insurance of malignant breast illnesses, benign ailments are mentioned when it comes to next breast melanoma improvement. The ebook stories all significant medical trials and summarizes the data they supply on early detection and administration of breast melanoma. shut consciousness can be given to the expanding value of molecular biology and genetics during this box. This version beneficial properties greater than thirty new members, fourteen new or thoroughly rewritten chapters, and extra clinically orientated chapters.
A significant other site will supply the absolutely searchable textual content and a picture bank.
Also incorporated with this variation is the Anatomical Chart Company's Breast Anatomy and problems Pocket Guide. This sturdy, moveable folding pocket advisor presents a visible and textual assessment of breast anatomy, problems, and breast self-examination. With a write-on, wipe-off laminated floor, this consultant is ideal for the on-the-go practitioner to teach sufferers, caregivers, and families.
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Additional info for Diseases of the Breast (4th Edition)
Sample text
The activated mammary gland specific nuclear factor (Mgf) enhances in vitro transcription of the beta-casein gene promoter. J Steroid Biochem 1993;47:21. Altiok S, Groner B. b-casein mRNA sequesters a single-stranded nucleic acid-binding protein which negatively regulates the b-casein gene promoter. Mol Cell Biol 1994;14:6004. Alford D, Taylor-Papadimitriou J. Cell adhesion molecules in the normal and cancerous mammary gland. J Mammary Gland Biol Neoplasia 1996;1:207. Nguyen DD, Neville MC. Tight junction regulation in the mammary gland.
Dickson RB, Lippman ME. Estrogenic regulation of growth and polypeptide growth factor secretion in humor breast carcinoma. Endocrine Rev 1987;8:29. Suchard M, Landers JP, Sandhu NP, Spelsberg TC. Steroid hormone regulation of nuclear proto-oncogenes. Endocrine Rev 1993;14:659. Waxman J, ed. Molecular endocrinology of cancer. Cambridge, UK: Cambridge University Press, 1996:1. Dickson RB, Salomon DS, eds. Hormones and growth factors in development and neoplasia. New York: Wiley-Liss, 1998:1. Dickson RB, Lippman ME.
The basally located, myoepithelial cells appear to present high levels of this enzyme on their surfaces. 63 In contrast, MMP-7 has an epithelial localization. 64 The MMPs are thought to play central roles in mammary development, particularly in the apoptotic process of tissue involution, where they contribute to dissolution of unwanted milk secretory cells. 64,65 As is discussed later in the text (see section Defective Regulation of Tissue Compartmentalization in Cancer ), breast cancer is characterized by progressive loss of controls of basement membrane and of hormones on proliferation and epithelial differentiation (a process termed an epithelial-mesenchymal transition), by genomic instability (mutations, deletions, amplifications, and chromosomal rearrangements), by alteration in nuclear matrix structure and function (to regulate gene transcription), and by loss of normal tissue organization and compartmentalization (metastasis).