By Brett L. Walker
Contributor note: ahead through William Cronon
----------------------
This interesting environmental historical past of Japan examines how traditions and practices in numerous industries
• from elevating silkworms to mining lead and coal to refining petroleum
• have affected the wellbeing and fitness of staff and those that have lived in those poisonous landscapes.
Brett Walker is Regents' Professor and division chairperson of heritage and philosophy on the collage of Montana, Bozeman. he's the writer of The misplaced Wolves of Japan.
Read or Download Toxic Archipelago: A History of Industrial Disease in Japan (Weyerhaeuser Environmental Books) PDF
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Additional resources for Toxic Archipelago: A History of Industrial Disease in Japan (Weyerhaeuser Environmental Books)
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Once the mechanism of a disease DIVERSE FUNDING MODELS 31 is understood, moreover, a proposed therapy must be testable. Cerezyme reverses the effect of Gaucher, but there are a number of diseases whose damage is not reversible, and the goal of a therapy is to slow the progression of the disease. Demonstrating decreased progression is very different statistically from showing reversal. Another challenge, alluded to earlier, is the practicality of running a clinical trial when the patient population is extremely small.
A therapy would have to be disease modifying and/or lifesaving. And it would have to be testable—a challenge given the small populations involved when one is dealing with rare diseases. Post-approval, Genzyme is committed to optimizing patient care, as opposed to simply convincing physicians that the treatment for their Gaucher patients is Ceredase. Thus the company seeks to facilitate an environment in which patients with Gaucher disease have a reasonable expectation of being seen and diagnosed by a disease expert so informed decisions can be made about therapy.
What are the truly neglected diseases? With 127 compounds in development, HIV/AIDS is not a neglected disease. For malaria there are only 30 drugs in development, many of which are in the early stages and have a high risk of failure. For tuberculosis (TB), and particularly drug-resistant TB, only 22 candidate drugs are in the pipeline. For truly neglected diseases, such as human African trypanosomiasis, Chagas disease, and dengue fever, the pipeline is very limited, including 5, 7, and 8 compounds, respectively.