By Ruth Singer
A whole direction on sewing—from threading a needle to couture hemmingFinally anyone has created each sewer's perfect better half: a entire publication on each point of hand and computing device sewing—from the main easy to the main advanced—with a latest aesthetic and 20 tasks besides. From basic tutorials to in-depth masterclasses, Ruth Singer packs in lesson after lesson on either useful and ornamental techniques.
The stitching Bible includes:
• Easy-to-use directions followed by way of thousands of gorgeous pictures detailing each degree of every technique•20 practical, trendy stitching tasks that illustrate some of the lessons—from a simple T-shirt transformation to a fancy handbag—making this a how-to advisor and trend publication in one
•Extensive publications to materials and instruments, and assets that will help you opt for the proper fabrics and kit on your projects
•Advice on utilizing natural and eco materials and dealing with recycled and classic materials With extra pleasure than conventional stitching manuals, and masses extra intensity than a ebook of tasks, the stitching Bible is an easy-to-use advisor that's as beautiful because it is complete. this is often the single ebook you would like no matter if you're a newbie, a professional, or at any place in among.
Read or Download The Sewing Bible: A Modern Manual of Practical and Decorative Sewing Techniques PDF
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Destabilization of CAG trinucleotide repeat tracts by mismatch repair mutations in yeast. Hum Mol Gen 1997; 6:349-355. 65. Pamiewski P, Jaworski A, Wells RD et at. CAG repeats determines the influence of mismatch repair on genetic instability. J Mol BioI 2000; 299(4):865-874. 66. Manley K, Shirley TL, Flaherty L et at. MSH2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice. Nature Genetics 1999; 23(4):471-473. 24 P. PARNIEWSKI AND P. STACZEK 67.
6. Oostra BA. Trinucleotide Diseases and Instability. Heidelberg: Springer-Verlag, 1998. 7. Cummings CJ, Zoghbi HY. Fourteen and counting: Unraveling trinucleotide repeat diseases. Hum Mol Genet 2000; 9:909-916. 8. Richards RI, Sutherland GR. Dynamic mutations: A new class of mutations causing human disease. Cell 1992; 70:709-712. 9. Sutherland GR, Richards RI. Simple tandem DNA repeats and human genetic disease. Proc Nat! Acad Sci USA 1995; 92:3636-3641. 10. McInnis MG. Anticipation: An old idea in new genes.
However, these length changes are still an order of magnitude smaller than would be expected for similar sized alleles at the human DM1 locus. 3,5 Nonetheless, the length changes observed in both the Dmtl62 and DM55 and DM300 lines are comparable to the dynamics observed at many of the more stable human loci such as the spinocerebellar ataxia type 3, spinal and bulbar muscular atrophy and dentatorubral pallidoluysian atrophy loci. 24 Thus, it currently remains unclear whether the large germline expansions observed at the human DM1 locus are reproducible in mice.