By Brahma N. Singh, Sharmila Shankar, Rakesh K. Srivastava (auth.), Rakesh Srivastava, Sharmila Shankar (eds.)
The major aim of this booklet is to supply a entire evaluate on stem cells and their function in tissue regeneration, homeostasis and treatment. furthermore, the position of melanoma stem cells in melanoma initiation, development and drug resistance are mentioned. The cellphone signaling pathways and microRNA regulating stem mobilephone self-renewal, tissue homeostasis and drug resistance also are pointed out. total, those stories will supply a brand new realizing of the effect of stem cells in tissue regeneration, affliction legislation, remedy and drug resistance in numerous human diseases.
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J Mol Signal 5:14 96. Terskikh AV, Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL (2001) From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci USA 98:7934–7939 97. Tu SM, Lin SH, Logothetis CJ (2002) Stem-cell origin of metastasis and heterogeneity in solid tumours. Lancet Oncol 3:508–513 98. Van Den Berg DJ, Sharma AK, Bruno E, Hoffman R (1998) Role of members of the Wnt gene family in human hematopoiesis. Blood 92:3189–3202 99. van der Lugt NM, Domen J, Linders K, van Roon M, Robanus-Maandag E, te Riele H, van der Valk M, Deschamps J, Sofroniew M, van Lohuizen M et al (1994) Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.
There are also perspectives for implementation of the stem cells transplantation in the treatment of loss of neurons due to the brain or spinal cord damage, as a result of the stroke and mechanical injury. In human, the early transplantation stem cells trials present a huge variety of outcomes ranging from significant clinical benefit to worsening of symptoms with severe side effects. As the pathophysiology differs in PD, ALS, MS and stroke, different cell sources for transplantation might be required for optimal clinical improvement.
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