By G. Ramadori, Pierluigi Ramadori (auth.), Jean-Francois Dufour, Pierre-Alain Clavien (eds.)
Signaling Pathways in Liver illnesses, 2d edition makes a speciality of signaling pathways that are relatively vital in liver ailments. contemporary growth introduced hepatology to new frontiers. The expanding frequency of surgical procedure on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to appreciate the molecular mechanisms at play in those events and the way they are often inspired. higher comprehension of the mobile mechanisms engaging in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is reflected through a dramatic raise in complexity. The quantity and scope of courses is intimidating and tough for busy contributors to extract a coherent framework. This publication will function a resource of data facilitating the examining of the literature and the making plans of trials. Translational medication implies wisdom of the molecular pursuits for novel healing thoughts. it's going to in addition stimulate extra study and result in higher trade among the laboratory, the medical ward and the operation room.
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Extra info for Signaling Pathways in Liver Diseases
Sample text
Although the fundamental role of MAPK signaling in growth of nonmalignant cells has been established in many types of cells and tissues, this topic has received little attention to date in the cholangiocyte. PI3-Kinase Signaling Increases in cell volume are known to activate phosphotidylinositol 3-kinase (PI3-K) [112]. PI3-K is a heterodimer that phosphorylates phosphotidylinositol upon activation, producing distinct phospholipid second messengers. Studies in a number of cell types show that this kinase is involved in controlling cell proliferation, organization of the actin cytoskeleton, regulation of vesicle trafficking between intracellular organelles, and a range of secretion-related processes [113].
Keppler D, Leier I, Jedlitschky G et al (1996) The function of the multidrug resistance proteins (MRP and cMRP) in drug conjugate transport and hepatobiliary excretion. Silverman JA (1999) Multidrug-resistance transporters. Redinger RN (2003) The coming of age of our understanding of the enterohepatic circulation of bile salts. Strazzabosco M, Boyer JL (1996) Regulation of intracellular pH in the hepatocyte. Mechanisms and physiological implications. J Hepatol 24(5):631–644 95. Bochkis IM, Rubins NE, White P et al (2008) Hepatocytespecific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.
This apparent inconsistency may be explained by the observation that ductular secretion in rats accounts for only ~10% of total bile flow [37]. Secretin receptors belong to the class of G proteincoupled receptors that activate adenylate cyclase to increase cAMP formation [38, 39]. Activation of the secretin receptor does not affect Cai2+ in isolated bile duct cells [40], nor does it affect cAMP production in hepatocytes [38]. Thus, in the liver these receptors are expressed only by cholangiocytes [38] and are localized to the basolateral membrane of these cells.