By Nady Braidy
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Extra info for Pomegranates: Old Age Remedy for Today’s Diseases
Sample text
Recently, these foods have gained popularity in the developed world due to the potential beneficial effects and strong anti-oxidant properties. The beneficial properties of pomegranate as listed on a number of websites selling pomegranate products to the consumer include its use as an antioxidant, an antiinflammatory and antiatherogenic treatment. Pomegranate-derived products have been advertised as exhibiting anti-cancer properties, improvement in 38 Nady Braidy cardiovascular health, diabetes prevention and management, relief of menopausal symptoms, hormone balance, increased libido in both genders, improved male virility and erectile function, skin nourishment including ant wrinkle effects, and protection against Alzheimer’s disease and rheumatoid arthritis.
Urolithin metabolites have been shown to be readily absorbed in mouse models, with the highest levels accumulated in prostate, colon, and intestinal tissues [74]. Similarly, urolithin A glucuronide, urolithin B glucuronide, and dimethylellagic acid were the only ellagic acid metabolites detected in human prostate tissues after three days of supplementation with pomegranate juice [75]. It is likely that ellagitannins are hydrolyzed in the stomach where some portion of ellagic acid may be absorbed into circulation.
2006. The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway. J Nutr Biochem, 17(9): 611–625. , Zhang, X. , Xing, D. , Xie, W. , Su, H. and Du, L. J. 2007. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int J Obes (Lond), 31(6): 1023–1029. , Huang, T. , Yamahara, J. and Roufogalis, B. D. 2008. Pomegranate flower: A unique traditional antidiabetic medicine with dual PPAR-alpha/-gamma activator properties.