By Patricia B. Hoyer
In recent times, there was an alarming bring up in environmental by-products that could be damaging to ovarian functionality. besides this harmful state of affairs, the trendy development towards delaying motherhood poses quick matters concerning the long term influence of environmental hazards on human fertility. The uncertainty of our reproductive destiny intensifies the necessity for a unmarried reference that investigates the chemical compounds with the aptitude to jeopardize fertility. the single recognized textual content that offers in particular with toxicity within the ovary, Ovarian Toxicology updates our present realizing of the consequences of environmental chemical compounds on ovarian functionality. This new name within the objective Organ Toxicology sequence provides an summary of ovarian body structure, examines the foremost ovarian goal websites, assesses the results of particular chemical compounds validated in animal stories, and evaluates comparable human epidemiological information. that includes the main whole assessment on hand of ovarian metabolism of xenobiotics, chapters additionally talk about ovarian melanoma and modeling and checking out for ovarian results. With its transparent dealing with of information and matters which are the most important to fertility reports, this complete exploration of ovarian toxicology identifies the reasonable hazards for harm that the environment has the aptitude to inflict. it is going to be welcomed by means of toxicologists and ovarian physiologists, these within the pharmaceutical industries and regulatory corporations, and postgraduate researchers striving to shield women's fertility and confirm our reproductive destiny.
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Extra info for Ovarian Toxicology (Target Organ Toxicology Series)
Example text
Appl. , 105:372–81. A. C. (1971) Amenorrhea in patients with Hodgkins disease treated with antineoplastic agents, Am. J. Obstet. , 109: 135–39. R. T. (1995) Menopause: its epidemiology and potential association with chronic diseases, Epidemiol. , 17:287–302. G. B. (1996a) Involvement of apoptosis in 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats, Toxicol. Appl. , 139:394–401. G. B. (1996b) Enhanced expression of bax in small preantral follicles during 4-vinylcyclohexene diepoxide-induced ovotoxicity in the rat, Toxicol.
1987). A primary effect at the ovarian level might cause a later disruption of this regulatory axis and FSH levels should increase due to loss of negative feedback from the ovarian hormones. 1). Although a greater than 90 percent loss of oocytes in small follicles was measured by 30 days, FSH levels were only first observed to be increased above control animals at 240 days. Therefore, ovarian changes preceded the rise in circulating FSH levels. Also at 240 days, vaginal cytology still displayed evidence of ovarian cyclicity in VCH-treated mice.
This is the natural fate of the majority of ovarian follicles because only a selected few follicles that develop will ever be ovulated (Hirshfield, 1991). This process, called atresia, can occur in follicles in all stages of development and can be morphologically distinguished from healthy follicles. , 1991). Thus, morphological changes of a cell undergoing atresia are those characteristic of apoptosis. , 1980). Therefore, this form of cell death is physiological and likely to go undetected by the organism.