By R. Slade
Christie Hospitol, Manchester, U.K.
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1991. 693-698. Causes of raised HCG include 143, 144, 145,146, 147 CIN 3 is characterized by 148,150, 151 (Premalignant diseaseof the cervix) Lymph node deposits and invasion through the basement membrane imply carcinoma. There are no histological changes beneath the basement membrane. Oligohydramnios is characteristically associated with 153, 154, 155 (Polyhydramnios/oligohydramnios) Oligohydramnios is also associatedwith labour and meconium aspiration. IUGR (83%), increased fetal distressin Reference Stark C.
Bands in DNA occur between adenine and guanine, and cytosine and thymidine. Although the majority of genetic mutations are single base substitutions. more subtle rearrangements of a gene may alter the structure of the mRNA and the protein synthesis. Restriction endonucleases cut DNA at different sites. Exons are important in coding for genetic products. Alpha-l-antitrypsin is the product of a highly polymorphic gene locus called PI (protease inhibitor) containing about 75 alleles. The common or wildtype form of alpha-antitrypsin is called PI-M.
If cardiomegaly persists at 5 years mortality is in excess of 80%. It is more common with multiple pregnancies,eclampsia and multiparity inwomen over 30 years. It normallypresentswith signs ofcongestivecardiac failure (fatigue, breathlessness and oedema). Treatment is supportivewith anti-hypertensives and diuretics. If treatment fails heart transplantation may be necessary. Reference Momson WL, Petch MC. Peripartum cardiomyopathy. Hospital update. 1991. 693-698. Causes of raised HCG include 143, 144, 145,146, 147 CIN 3 is characterized by 148,150, 151 (Premalignant diseaseof the cervix) Lymph node deposits and invasion through the basement membrane imply carcinoma.