By C. William Helm, Robert Edwards
Intraperitoneal melanoma treatment investigates intraperitoneal chemotherapy in various complicated and fascinating methods. the quantity info significant medical trails to this point, together with immunotherapy, hyperthermic remedy of colo-rectal and ovarian cancers. Authors additionally study local ways to treatment, systemic remedy, and using carboplatin and paclitaxel because the normal remedy for ladies with levels III and IV ovarian melanoma. different chapters additionally examine strategies and approaches in remedy, in addition to the long run path of either normothermic and hyperthermic intraperitoneal chemotherapy.
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Extra info for Intraperitoneal Cancer Therapy (Current Clinical Oncology)
Sample text
Ozols RF, Speyer JL, Jenkins J, et al. Phase II trial of 5-FU administered IP to patients with refractory ovarian cancer. Cancer Treat Rep 1984;68:1229–1232. indd 28 5/9/2007 2:02:25 PM Management of Ovarian Cancer: Clinical Trials 29 59. Alberts DS, Liu PY, Hannigan EV, et al. Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for stage III ovarian cancer. N Engl J Med 1996;335:1950–1955. 60. McGuire WP, Hoskins WJ, Brady MF, et al.
It is essential to note that any such comparisons (to be described later in this chapter) are merely “hypothesis generating,” or supportive of further clinical investigation. In the absence of data from prospective randomized phase III trials examining the impact of treatment on survival, it is completely unknown if the observation of “additional tumor cell kill” actually benefits patients. As rather accurately predicted by the preclinical studies, substantially more “biological activity” (surgically defined tumor shrinkage, conversion of “positive” second-look laparotomies to “negative” third-look procedures) was observed for second-line IP cisplatin in patients with small-volume disease, compared with those individuals with larger tumor masses (47).
J Clin Oncol 1995;13:1589–1599. 27. Gore M, Mainwaring P, A’Hern R, et al. Randomized trial of dose-intensity with single-agent carboplatin in patients with epithelial ovarian cancer. London Gynaecological Oncology Group. J Clin Oncol 1998;16:2426–2434. 28. Jakobsen A, Bertelsen K, Andersen JE, et al. Dose-effect study of carboplatin in ovarian cancer: A Danish Ovarian Cancer Group study. J Clin Oncol 1997;15:193–198. 29. Joly F, Heron JF, Kerbrat P, et al. High-dose platinum versus standard dose in advanced ovarian carcinoma: a randomized trial from the Gynecologic Cooperative Group of the French Comprehensive Cancer Centers (FNCLCC).