By Joint Committee on Vaccination and Immunisation, Great BritainDepartment of Health
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2004) Safety of DTaP-based combined immunization in very-low-birth-weight premature infants: frequent but mostly benign cardiorespiratory events. J Pediatr 145(1): 58-66. Pourcyrous M, Korones SB, Arheart KL et al. (2007) Primary immunization of premature infants with gestational age <35 weeks: cardiorespiratory complications and C-reactive protein responses associated with administration of single and multiple separate vaccines simultaneously. J Pediatr 151(2): 167-72. Schulzke S, Heininger U, Lucking-Famira M et al.
Schulzke S, Heininger U, Lucking-Famira M et al. (2005 ) Apnoea and bradycardia in preterm infants following immunisation with pentavalent or hexavalent vaccines. Eur J Pediatr 164(7): 432-5. 54 Introduction Vaccines induce protection by eliciting active immune responses to specific antigens. There may be predictable adverse reactions (side effects): most are mild and resolve quickly. However, it is not always possible to predict individuals who might have a mild or serious reaction to a vaccine.
Prematurity It is important that premature infants have their immunisations at the appropriate chronological age, according to the schedule. The occurrence of apnoea following vaccination is especially increased in infants who were born very prematurely. Very premature infants (born ≤ 28 weeks of gestation) who are in hospital should have respiratory monitoring for 48-72 hrs when given their first immunisation, particularly those with a previous history of respiratory immaturity. , 2008). As the benefit of vaccination is high in this group of infants, vaccination should not be withheld or delayed.