By Esther K. Smith

From zines you could fold in a minute to sumptuous leather-based journals and magnificent sketchbooks, How to Make Books will stroll you thru the simple fundamentals of bookmaking. even if you’re a author, a scrapbooker, a political activist, or a postcard collector, permit publication artist Esther okay. Smith be your consultant as you find your internal bookbinder. utilizing foolproof illustrations and step by step directions, Smith finds her time-tested ideas in a enjoyable, easy-to-understand approach.

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Destabilization of CAG trinucleotide repeat tracts by mismatch repair mutations in yeast. Hum Mol Gen 1997; 6:349-355. 65. Pamiewski P, Jaworski A, Wells RD et at. CAG repeats determines the influence of mismatch repair on genetic instability. J Mol BioI 2000; 299(4):865-874. 66. Manley K, Shirley TL, Flaherty L et at. MSH2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice. Nature Genetics 1999; 23(4):471-473. 24 P. PARNIEWSKI AND P. STACZEK 67.

6. Oostra BA. Trinucleotide Diseases and Instability. Heidelberg: Springer-Verlag, 1998. 7. Cummings CJ, Zoghbi HY. Fourteen and counting: Unraveling trinucleotide repeat diseases. Hum Mol Genet 2000; 9:909-916. 8. Richards RI, Sutherland GR. Dynamic mutations: A new class of mutations causing human disease. Cell 1992; 70:709-712. 9. Sutherland GR, Richards RI. Simple tandem DNA repeats and human genetic disease. Proc Nat! Acad Sci USA 1995; 92:3636-3641. 10. McInnis MG. Anticipation: An old idea in new genes.

However, these length changes are still an order of magnitude smaller than would be expected for similar sized alleles at the human DM1 locus. 3,5 Nonetheless, the length changes observed in both the Dmtl62 and DM55 and DM300 lines are comparable to the dynamics observed at many of the more stable human loci such as the spinocerebellar ataxia type 3, spinal and bulbar muscular atrophy and dentatorubral pallidoluysian atrophy loci. 24 Thus, it currently remains unclear whether the large germline expansions observed at the human DM1 locus are reproducible in mice.

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How to Make Books: Fold, Cut & Stitch Your Way to a by Esther K. Smith
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