By Mohd Rushdan Md Noor, Tay Eng Hseon, Low Jen Hui Jeffrey
Gynaecologic oncology is among the most crucial matters in gynaecology and a really difficult box. The administration of sufferers with gynaecological cancers is advanced, because the impression of the result of such cancers might be severe. This guide covers the fundamentals of carcinogenesis and the advances within the prevention and administration of all gynaecologic cancers, together with breast melanoma. Gynaecologic oncology has Read more...
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Extra resources for Gynaecologic Cancer: A Handbook for Students and Practitioners
Example text
Therefore, telomerase prevents shortening of the DNA during each cell reproduction. Telomerase is almost undetectable in most normal somatic cells and increase telomerase expression produces vulnerability of uncontrolled cell division and malignant transformation. In contrast, inhibition of telomerase may limits the growth of human cancer celis. Research on anti-telomerase or telomerase inhibitor as one of the anti-cancer therapy is ongoing. Genetic Studies in Gynaecologic Malignancies Ovarian Cancer In ovarian cancer, there are two types of genetic alterations either inheritance (familial) or somatic mutation (sporadic) and approximately, 90% of ovarian cancers are sporadic.
9 10 World Cancer Statistics and Burden of Gynaecological Cancer • Prevalence: Prevalence is deϐined as the total number of cases of the disease in the population at a given time, or the total number of cases in the population, divided by the number of individuals in the population. It is used as an estimate of how common a condition is within a population over a certain period of time. • Mortality: Mortality is the number of deaths that occur in a given period in a speciϐied population. It can be expressed as an absolute number of deaths per year or as a rate per 100,000 persons per year.
MMP also causes enzymatic action of the basement membranes of the vessel to allow cancer cell enter into the blood stream or lymphatic channels. Apoptosis Apoptosis or programmed cell death is one of mechanism by which organism limits the growth and replication of the cellls. Apoptosis occur in normal cell allows to removed the damaged cells and maintain the balance between cell death and cell proliferation. In average human adult, there are 50–70 billion cells undergo Genetic Studies in Gynaecologic Malignancies apoptosis everyday.