By Neil Kaplowitz, Laurie D. DeLeve
That includes greater than 4100 references, Drug-Induced Liver disorder could be a useful reference for gastroenterologists, hepatologists, relations physicians, internists, pathologists, pharmacists, pharmacologists, and medical toxicologists, and graduate and scientific college scholars in those disciplines.
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Extra resources for Drug-Induced Liver Disease (2nd Edition)
Example text
Eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. New York: McGraw-Hill, 1996:3–29. 6. Bertz RJ, Granneman GR. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Clin Pharmacokinet 1997; 32:210–258. The Role of Cytochrome P450s 29 7. Tanaka E. Update: genetic polymorphism of drug metabolizing enzymes in humans. J Clin Pharm Ther 1999; 24:323–329. 8. Meyer UA, Zanger UM. Molecular mechanisms of genetic polymorphisms of drug metabolism.
There are large interindividual differences in the activity profile of the liver P450s, and in many instances, this variation appears to account for interpatient differences in the pharmacokinetics of medications (5). The variation among patients in the activities of specific P450s can reflect both genetic and nongenetic factors. V. GENETIC FACTORS INFLUENCING P450 ACTIVITY Genetic mutations in part explain why there are large interindividual differences in the activities of many of the P450s (7–10).
9. Hasler JA. Pharmacogenetics of cytochromes P450. Mol Aspects Med 1999; 20:12–24, 25– 137. 10. Evans WE, Relling MV. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 1999; 286:487–491. 11. Marez D, Legrand M, Sabbagh N, et al. Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics 1997; 7:193–202. 12. Chida M, Yokoi T, Kosaka Y, et al. Genetic polymorphism of CYP2D6 in the Japanese population.