By Robert Baran, R. P. R. Dawber, David de Berker, Ekhart Haneke, Antonella Tosti
This re-creation brings jointly 5 top specialists in nail surgical procedure during this good confirmed and definitive textbook.The complete textual content is prolonged during this version, and specific emphasis is put on the advances in remedies that experience taken position in recent times. enormous strides were made within the remedy of fungal ailments (onychomycoses) with the looks of latest healing brokers. there's additionally a lot better insurance of nail surgical procedure to mirror the expanding involvement of the dermatologist during this box. The part on nail tumours has additionally been expanded.Drs Baran and Dawber were joined through David de Berker, Eckhart Haneke and Antonella Tosti at the editorial group. This flow is consultant of the most important eu contribution to the sphere of nail surgical procedure lately. major contribution has come from Dr Elvin Zook, the eminent American hand medical professional, who has helped to make sure that the ebook is as suitable in North the USA because it is in Europe.
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Additional info for Diseases of the Nails and Their Management 3rd Edition
Example text
Those of molecular weights 76, 73, 64, 61 and 55 kDa were common to hair and nail. One component of 61 kDa was specific to hair, and two components, both with a molecular weight of 50 kDa, were specific to nail. Further definition of these proteins was given by Heid et al. (1988) who employed gel electrophoresis, immunoblotting, peptide mapping and 24 CHAPTER 1 Fig. 28 Models of hair follicle/nail unit homology. Fig. (b) the nail unit (x10) and (c) the human lingual papilla (~500). (After Westgate eta/.
A considerable amount of biochemical work on hair and nail illustrates this point. In one study (Dekio & Jidoi 1989) two-dimensional electrophoresis was used to determine the presence of nine keratins in human hair and nail. Those of molecular weights 76, 73, 64, 61 and 55 kDa were common to hair and nail. One component of 61 kDa was specific to hair, and two components, both with a molecular weight of 50 kDa, were specific to nail. Further definition of these proteins was given by Heid et al. (1988) who employed gel electrophoresis, immunoblotting, peptide mapping and 24 CHAPTER 1 Fig.
1988; Westgate et al. The relative resilience of the two groups of keratins is also reflected in their solubility in 2-mercaptoethanol. At 50 mmol/L concentrations, only epithelial ‘soft’ keratins are extracted from nail clippings. The concentration needs to be raised to 200 mmol/L before significant quantities of ‘hard’ keratin dissolve (Kitahara & Ogawa 1991). The main lipid of nail is cholesterol. 1-1%, contrasting with the 10% found in the stratum corneum. The water content is less than that of skin, being 7-12% compared with 15-25%.