By Peter Gluckman, Mark Hanson
This landmark booklet offers the 1st definitive account of ways and why refined affects at the fetus and through youth could have such profound effects for grownup wellbeing and fitness and illnesses. even supposing the epidemiological proof for this hyperlink has lengthy proved compelling, it is just even more lately that the medical and physiological foundation has all started to be studied extensive and completely understood. The compilation, written via the various world's top specialists during this interesting box, summarizes those clinical and medical advances.
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Extra info for Developmental Origins of Health and Disease
Sample text
Birth length and weight have been associated with later asthma (Leadbitter et al. 1999), but this was not replicated in another study (Svanes et al. 1998). The conflicting results may reflect the age at which the relationship is examined, and whether persistent wheezing associated with atopy is considered separately from transient wheezing in children with small airways 19 20 K. Godfrey who are predisposed to wheeze with viral infections (Martinez et al. 1995). Cognitive function and mental health Brain growth and cognitive function in childhood and old age There is evidence that elderly adults with larger head sizes not only tend to gain higher scores on tests of IQ and memory function, but are also less likely to show a decline in these scores over time (Gale et al.
Recent studies suggest that, in addition to its associations with compliance, low birthweight is also associated with persisting alterations in vascular structure and function. Hertfordshire men who had had low birthweight had narrow bifurcation angles in their retinal blood vessels (Chapman et al. 1997). People with hypertension have similar changes in retinal vascular geometry. In the search for mechanisms which link reduced early growth with cardiovascular disease, evidence has emerged suggesting that functional abnormalities of the vasculature may be important.
1998). The normal physiological growth and development patterns of the airways and parenchyma remain poorly understood, but epidemiological studies measuring premorbid lung function in infancy indicate the importance of genetic and environmental factors during fetal and early postnatal life (Clarke et al. 1995, Stick et al. 1996, Dezateux et al. 1999). 4 s and lower forced expiratory flow at functional residual capacity (Lucas et al. 2004): these suggest impaired lung development and may predispose to obstructive airways disease, including asthma.