By Dr. Luigi Solbiati, Dr. Alberto Martegani, Dr. Edward Leen, Dr. Jean Michel Correas, Dr. Peter N. Burns, Dr. Dirk Becker (auth.)
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Additional info for Contrast-Enhanced Ultrasound of Liver Diseases
Sample text
Amersham) Levovist (Schering) Sonovue (Bracco) Definity (Bristol Myers Squibb) Imagent (Alliance/Schering/Cardinal) LVO, not marketed LVO Doppler enhancement LVO, macrovascular and microvascular imaging LVO (USA and Canada), liver and kidney (Canada only) LVO (USA only) LVO, Left Ventricular Output trast media as they are not distributed throughout the body fluid but remain in the blood pool or in the body cavities to which they are applied. Therefore, the main areas of application are in echo enhancement of the blood flow in the heart chambers and blood vessels (blood pool contrast agents) and in the imaging of body cavities.
IEEE Trans". IEEE Transaction on Ultrasonics, Ferroelectrics, and Frequency Control 29:95-101 Hope Simpson D, Chin CT, Burns PN (1999) Pulse inversion doppler: a new method for detecting nonlinear echoes from microbubble contrast agents. IEEE Transactions UFFC 46:372-382 Kono Y, Moriyasu F, Nada T, Suginoshita Y, Matsumura T, Kobayashi K, Nakamura T, Chiba T (1997) Gray scale second harmonic imaging of the liver: a preliminary animal study. Ultrasound Med Bioi 23(5):719-726 Miller DL, Gies RA, Chrisler WB (1997) Ultrasonically induced hemolysis at high cell and gas body concentrations in a thin-disk exposure chamber.
1 Introduction With the advent of new ultrasound contrastspecific scanning modes, the clinical potential of ultrasound contrast agents has been widely enhanced and the efficacy has been potentiated. Ultrasound contrast agents are based on microbubbles with a diameter of a few micrometers. Their efficacy was previously described mainly as echoenhancers for Doppler signals, and by enhancing the reflectivity of blood, the signal-to-noise ratio for Doppler signals can be enhanced and a clear Doppler trace may be obtained in otherwise difficult to scan patients.