By Stewart Wolf, Allen K. Murray
The current quantity includes the edited transcript of a Totts hole Colloquium held may possibly 19-21, 1980 backed through the Muscular Dystrophy organization. the purpose of the colloquium was once to deliver into concentration information in terms of telephone membranes that may give a contribution to realizing the pathogenic mechanism of Duchenne muscular dystrophy. an enormous obstacle to growth in figuring out the patho genesis of muscular dystrophy has been the failure, up to now, to spot the elemental genetic disorder. Pending the identity of the genetic lesion in Duchenne dystrophy and, in view of scattered yet chronic symptoms of a simple membrane disturbance, it appeared useful to discover in open discussion the present country of data of membrane morphology and chemistry with an eye fixed to attainable leads for additional research. The members, drawn from a number of disciplines, tried to synthesize and reconcile their findings and to spot the most important components of lack of knowledge short of exploration. For the main half they shunned really expert jargon and spoke in a language which may be understood by means of the remainder of the crowd. except offering a evaluate of broadly various methods to the examine of the composition and behaviour of mobilephone membranes, the discussions introduced jointly present think~g on options and ways to the learn of the pathogenesis of muscular dystrophy. Already the non-public contacts made on the colloquium have ended in new inter-institutional collabora tive investigations.
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Extra resources for Composition and Function of Cell Membranes: Application to the Pathophysiology of Muscle Diseases
Sample text
TT - Ttubule; Te - terminal cisternae of SR; LSR lateral cisternae of SR. measurable. The membrane component which forms the phosphoenzyme intermediate should be identified. The rates of ea 2+ uptake as well as ATP hydrolysis by SR can be measured. The efficiency of ea 2+ transport, i. P hydrolyzed is 2 in isolated SR. The catalytic cycle is more complex than shown, consisting of at least 8 steps. , 1973). , 1973; Meissner, 1973). Thus the calcium pump protein contains some key requisites for the Ca 2+ pumping molecule.
Similar to many actin binding proteins in being able to cross-link actin filaments and also in having an elongate floppy shape. The general distribution of the polypeptides of the erythrocyte membrane was reviewed by Ted Steck in 1975. Band 3 and PAS 1 are two major transmembrane proteins but most of the polypeptides I spoke of are on the inside surface. Spectrin itself is an elongate floppy molecule which can be visualized in the electron microscope by drying out of gly~erol and low angle rotary shadowing.
1981). 47 PHYLOGENY, STRUCTURE AND COMPOSITION OF CELL MEMBRANES ,, , NORMAL-SR ,, RECONSTITUTED-SR , PHOSPHOLIPID E TANNIC ACID FIXATION I , I I : NEGATIVE: STAINING: I I I A NORMAL-SR RECONSTITUTED-SR B Figure 1-21: Diagrammatic representation of normal and reconstituted SR membranes: A. Normal and reconstituted SR as visualized by negative staining and in thin section electron microscopy using tannic acid. The 40-A particles observed with negative staining (Frames A and D) and the broadened outer band in thin section using tannic acid extend 50 from the surface (Frames B and C), compared with phospholipid (Frame E).