By Francis Ali-Osman
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Nat. Genet. 21:33–37. 7. , et al. 1998. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J. Natl. Cancer Inst. 90:1473–1479. 8. G. 1999. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. USA 96:4240–4245. 9. , Brieger J. 1997. The von Hippel-Lindau tumor suppressor gene. A rare and intriguing disease opening new insight into basic mechanisms of carcinogenesis.
Genet. 15:356–362. 86. , et al. 1998. Selective sensitivity to radiation of cerebral glioblastomas harboring p53 mutations. Cancer Res. 58:1793–1797. 87. M. 1998. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280:1614–1617. 88. , et al. 1997. Molecular genetic analysis of the von Hippel-Lindau disease tumor suppressor gene in familial and sporadic cerebellar hemangioblastomas. Am. J. Clin. Pathol. 107:459–466. 89. Ueki K. , et al. 1996. CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.
Sporadic medulloblastomas contain PTCH mutations. Cancer Res. 57:842–845. 66. , et al. 1993. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res. 53:2736–2739. 67. , et al. 1994. Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2. Cancer Res. 54:4299–4303. 68. , et al. 1994. Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p.